Drug Information
Drug General Information | |||||
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Drug ID |
D06ZWG
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Former ID |
DCL000709
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Drug Name |
AVE-5997EF
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Drug Type |
Small molecular drug
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Indication | Schizophrenia [ICD9: 295; ICD10:F20] | Terminated | [1] | ||
Company |
Sanofi-Aventis
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Structure |
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Download2D MOL |
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Formula |
C25H29F3N4OS
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Canonical SMILES |
CC1=CC=C(C=C1)NC(=O)NCCCCN2CCN(CC2)C3=CSC4=C3C=CC(=C4)C<br />(F)(F)F
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InChI |
1S/C25H29F3N4OS/c1-18-4-7-20(8-5-18)30-24(33)29-10-2-3-11-31-12-14-32(15-13-31)22-17-34-23-16-19(25(26,27)28)6-9-21(22)23/h4-9,16-17H,2-3,10-15H2,1H3,(H2,29,30,33)
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InChIKey |
XVFIYMFVLGFALY-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | D(3) dopamine receptor | Target Info | Antagonist | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Dopaminergic synapse | |||||
Reactome | Dopamine receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
Nicotine Activity on Dopaminergic Neurons | |||||
GPCRs, Other | |||||
References | |||||
REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. | ||||
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