Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06ZWG
|
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| Former ID |
DCL000709
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| Drug Name |
AVE-5997EF
|
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| Drug Type |
Small molecular drug
|
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| Indication | Schizophrenia [ICD9: 295; ICD10:F20] | Terminated | [1] | ||
| Company |
Sanofi-Aventis
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H29F3N4OS
|
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| Canonical SMILES |
CC1=CC=C(C=C1)NC(=O)NCCCCN2CCN(CC2)C3=CSC4=C3C=CC(=C4)C<br />(F)(F)F
|
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| InChI |
1S/C25H29F3N4OS/c1-18-4-7-20(8-5-18)30-24(33)29-10-2-3-11-31-12-14-32(15-13-31)22-17-34-23-16-19(25(26,27)28)6-9-21(22)23/h4-9,16-17H,2-3,10-15H2,1H3,(H2,29,30,33)
|
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| InChIKey |
XVFIYMFVLGFALY-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | D(3) dopamine receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Dopaminergic synapse | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. | ||||
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