Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07ALU
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| Former ID |
DIB018336
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| Drug Name |
[3H]methotrexate
|
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| Synonyms |
[3H]-methotrexate
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [467912] | ||
| Formula |
C20H22N8O5
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| InChI |
InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
|
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| InChIKey |
FBOZXECLQNJBKD-ZDUSSCGKSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5042, 67627, 585459, 585463, 602572, 826993, 831594, 835286, 836777, 837147, 3138774, 7847210, 7889076, 7979933, 8028432, 8029193, 8029470, 8149420, 10241686, 10321387, 11110523, 11113978, 11120366, 11120854, 11121342, 11335289, 11360528, 11364750, 11367312, 11369874, 11371593, 11374311, 11378039, 11447411, 11461500, 11466163, 11467283, 11484830, 11485885, 11488893, 11490313, 11492431, 11495650, 14760074, 14808762, 17404585, 22395177, 24897373, 24902354, 26680792
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| Target and Pathway | |||||
| Target(s) | Proton-coupled folate transporter | Target Info | Modulator | [543374] | |
| Reduced folate transporter 1 | Target Info | Modulator | [534589] | ||
| References | |||||
| Ref 534589 | Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells. J Biol Chem. 1998 Apr 3;273(14):8106-11. | ||||
| Ref 543374 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). | ||||
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