Drug Information

Drug General Information
Drug ID
D07AXA
Former ID
DIB007833
Drug Name
Fatty acid amide hydrolase inhibitors
Synonyms
Fatty acid amide hydrolase inhibitors (pain/inflammation); FAAH inhibitors (pain/inflammation), Amgen; Fatty acid amide hydrolase inhibitors (pain/inflammation), Amgen
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [552100]
Company
Amgen Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
n1(c(=O)n(c2c1cccc2)CC)C1CN(c2nccc(n2)c2cc3c(o2)cccc3)C<br />CC1
Target and Pathway
Target(s) Fatty-acid amide hydrolase Target Info Inhibitor [543418]
BioCyc Pathway Anandamide degradation
KEGG Pathway Retrograde endocannabinoid signaling
PANTHER Pathway Anandamide degradation
References
Ref 552100Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84
Ref 543418(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).

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