Drug General Information
Drug ID	D07BIK
Former ID	DIB016422
Drug Name	VEL-0230
Synonyms	NC-2300; Osteoporosis therapy (oral), Velcura/Nippon Chemiphar
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Phase 1	[551545]
Company	Nippon Chemiphar Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C14H24NNaO5
Canonical SMILES	O1[C@@H]([C@H]1C(=O)N[C@@H](CC(C)C)COCC(C)C)C(=O)[O-].[<br />Na+]
CAS Number	CAS 221144-20-3
PubChem Compound ID	25102841
Target and Pathway
Target(s)	Cathepsin K	Target Info	Inhibitor	[526178]
KEGG Pathway	Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritis
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling Pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Trafficking and processing of endosomal TLR
	MHC class II antigen presentation
WikiPathways	RANKL/RANK Signaling Pathway
	Osteoclast Signaling
References
Ref 551545	Velcura Therapeutics, Inc. to Begin Clinical Trials in Rheumatoid Arthritis Patients. Velcura Therapeutics, Inc. JANUARY 07, 2009.
Ref 526178	Discovery and parallel synthesis of a new class of cathepsin K inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4.

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