TTD | Drug: D07BKH

Drug General Information
Drug ID	D07BKH
Former ID	DIB018081
Drug Name	(hydroxymethylphenyl)agomelatine
Synonyms	compound 21 [PMID: 18778943]
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542841]
Structure		Download 2D MOL
Formula	C22H23NO3
InChI	InChI=1S/C22H23NO3/c1-15(25)23-9-8-19-12-20(17-5-3-4-16(10-17)14-24)11-18-6-7-21(26-2)13-22(18)19/h3-7,10-13,24H,8-9,14H2,1-2H3,(H,23,25)
InChIKey	BHDVJMSEODZSTD-UHFFFAOYSA-N
PubChem Compound ID	9798456
PubChem Substance ID	14754170, 24107908, 44834463, 79784130, 103625143, 104111912, 231704973, 244882751, 249565605
Target and Pathway
Target(s)	Melatonin receptor	Target Info	Antagonist	[529678]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Circadian entrainment
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542841	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7922).
Ref 529678	Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8339-48.

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Drug Information