Drug Information

Drug General Information
Drug ID
D07BPS
Former ID
DAP000730
Drug Name
Suprofen
Synonyms
Maldocil; Masterfen; Profenal; Srendam; Sulproltin; Suprocil; Suprofene; Suprofenum; Suprol; Sutoprofen; R 25061; R25061; TN 762; TN762; Profenal (TN); R-25061; Suprofene [INN-French]; Suprofenum [INN-Latin]; TN-762; TYN-762P; P-2-Thenoylhydratropic acid; R-25,061; Suprofen (JAN/USP/INN); Suprofen [USAN:BAN:INN:JAN]; Alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid; (+-)-2-(p-(2-Thenoyl)phenyl)propionic acid; (-)-alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid; (R)-(Thien-2-ylcarbonyl)propionic acid; (S)-2-(4-(Thien-2-ylcarbonyl)phenyl)butyric acid; 2-(4-(2-Thenoyl)phenyl)propionsaeure; 2-(4-(2-Thienylcarbonyl)phenyl)propanoic acid; 2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid; 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid; 4-(2-Thenoyl)hydratropsaeure
Drug Type
Small molecular drug
Indication Miosis during ocular surgery; Dysmenorrhea [ICD9: 379.42, 625.3; ICD10:H57.03, N94.4-N94.6] Approved [542318], [550764], [551871]
Therapeutic Class
Antiinflammatory Agents
Structure
Download
2D MOL

3D MOL
Formula
C14H12O3S
InChI
InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
InChIKey
MDKGKXOCJGEUJW-UHFFFAOYSA-N
CAS Number
CAS 40828-46-4
PubChem Compound ID
5359
PubChem Substance ID
9528, 224830, 453324, 3180764, 7672824, 7847518, 8149755, 8153294, 10321232, 11335651, 11360890, 11364051, 11366613, 11369175, 11372035, 11374691, 11377337, 11461862, 11466844, 11467964, 11485276, 11486368, 11489246, 11490743, 11492841, 11494971, 12012657, 14848020, 26612210, 26679843, 26748525, 26748526, 29224411, 46508210, 47365135, 47662231, 47736424, 47810708, 47810709, 48035064, 49698781, 49977399, 50025833, 50107425, 56459397, 56463227, 57322736, 74790379, 85787329, 92124483
SuperDrug ATC ID
M01AE07
SuperDrug CAS ID
cas=040828464
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Inhibitor [535392]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 542318(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7298).
Ref 550764Drug information of Suprofen, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535392Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model. 2002 Mar;20(5):359-71.

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