Drug General Information
Drug ID	D07CFJ
Former ID	DNC007184
Drug Name	1-propionyl-1H-indole-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528749]
Structure		Download 2D MOL 3D MOL
Formula	C11H9NO3
Canonical SMILES	CCC(=O)N1C2=CC=CC=C2C(=O)C1=O
InChI	1S/C11H9NO3/c1-2-9(13)12-8-6-4-3-5-7(8)10(14)11(12)15/h3-6H,2H2,1H3
InChIKey	IHNYAHBLLCMRCD-UHFFFAOYSA-N
PubChem Compound ID	589576
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528749]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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