Drug Information

Drug General Information
Drug ID
D07DUU
Former ID
DAP001289
Drug Name
Alglucosidase alfa
Synonyms
Lumizyme (TN); Myozyme (TN)
Indication Pompe's disease; Type 2 glycogen storage disease [ICD9: 271; ICD10:E74.02, E74.0] Approved [528715], [538381], [542561]
Therapeutic Class
Enzyme Replacement Agents
Company
Genzyme Corporation
Formula
C4758H7262N1274O1369S35
CAS Number
CAS 420784-05-0
SuperDrug ATC ID
A16AB07
Target and Pathway
Target(s) Mannose-6-phosphate receptor Target Info Binder [537500]
KEGG Pathway Lysosome
Phagosome
Reactome Lysosome Vesicle Biogenesis
References
Ref 5287152006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
Ref 538381FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (BLA) 125141.
Ref 542561(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7561).
Ref 537500Early Treatment with Alglucosidase Alfa Prolongs Long Term Survival of Infants with Pompe Disease. Pediatr Res. 2009 Jun 17.

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