Drug General Information
Drug ID	D07EHV
Former ID	DIB011733
Drug Name	LGH-447
Indication	Multiple myeloma [ICD9: 203; ICD10:C90]		Phase 1/2	[524766]
Company	Novartis
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Serine/threonine-proteinkinase pim-2	Target Info	Modulator	[532650]
KEGG Pathway	Acute myeloid leukemia
NetPath Pathway	IL1 Signaling Pathway
	TCR Signaling Pathway
	IL2 Signaling Pathway
WikiPathways	Hematopoietic Stem Cell Differentiation
References
Ref 524766	ClinicalTrials.gov (NCT02144038) Study of the Safety and Effectiveness of LGH447 and BYL719 in Patients With Relapsed and Refractory Multiple Myeloma. U.S. National Institutes of Health.
Ref 532650	Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20(7):1834-45.

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