Drug Information

Drug General Information
Drug ID
D07ESH
Former ID
DCL000594
Drug Name
PF-1913539
Drug Type
Small molecular drug
Indication Alzheimer disease; Huntington's disease [ICD9: 331, 294.1, 333.4; ICD10:G30, F02.2, G10] Discontinued in Phase 3 [548096]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C18H15N7O
Canonical SMILES
C1=CC=C(C=C1)CCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5
InChI
1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
InChIKey
UTLPKQYUXOEJIL-UHFFFAOYSA-N
PubChem Compound ID
176408
PubChem Substance ID
7980583, 10258377, 14900558, 26753254, 33500024, 47510090, 47731275, 50068074, 57395307, 76160696, 85209294, 85286114, 85788185, 90341001, 91746416, 99431535, 103180831, 103978930, 104425548, 121362004, 126671705, 129418187, 134339148, 134340512, 134341517, 135153621, 135651030, 135651205, 135697574, 142362474, 144240144, 144240145, 162023190, 162223707, 163124439, 163565213, 164759434, 170474553, 175612758, 176225385, 179294000, 184538735, 196376772, 198945991, 202558330, 204360450, 215780619, 223454701, 223519245, 223660679
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Antagonist [535907], [549974]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548096Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021875)
Ref 535907Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med. 2003 Nov;136(5):474-7.
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.

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