Drug Information

Drug General Information
Drug ID
D07HTM
Former ID
DIB018059
Drug Name
(-)-Ro 363
Synonyms
RO 363
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540948]
Structure
Download
2D MOL
Formula
C19H25NO6
InChI
InChI=1S/C19H25NO6/c1-24-18-6-3-13(9-19(18)25-2)7-8-20-11-14(21)12-26-15-4-5-16(22)17(23)10-15/h3-6,9-10,14,20-23H,7-8,11-12H2,1-2H3
InChIKey
RFNBEBPVKCJZPV-UHFFFAOYSA-N
PubChem Compound ID
156297
PubChem Substance ID
15052435, 24515973, 46232125, 50065148, 76183632, 81065476, 104443460, 125705237, 135112175, 162908313, 178102207
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [534368]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540948(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5571).
Ref 534368Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors. Br J Pharmacol. 1997 Jan;120(2):165-76.

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