Drug Information

Drug General Information
Drug ID
D07IAK
Former ID
DIB020656
Drug Name
PD 168368
Synonyms
PD168368; PD-168368
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541379]
Structure
Download
2D MOL
Formula
C31H34N6O4
InChI
InChI=1S/C31H34N6O4/c1-30(19-22-20-33-26-10-4-3-9-25(22)26,36-29(39)35-23-12-14-24(15-13-23)37(40)41)28(38)34-21-31(16-6-2-7-17-31)27-11-5-8-18-32-27/h3-5,8-15,18,20,33H,2,6-7,16-17,19,21H2,1H3,(H,34,38)(H2,35,36,39)/t30-/m0/s1
InChIKey
AFDXUTWMFMAQJO-PMERELPUSA-N
PubChem Compound ID
9937534
PubChem Substance ID
14910724, 24211305, 79169278, 103294457, 103965445, 127397766, 135650803, 135698676, 142335338, 231991415, 241051112
Target and Pathway
Target(s) Gastrin-releasing peptide receptor Target Info Antagonist [525567]
Bombesin receptor Target Info Antagonist [530159]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 541379(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 621).
Ref 525567Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. J Pharmacol Exp Ther. 1999 Sep;290(3):1202-11.
Ref 530159Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides. 2009 Aug;30(8):1473-86.

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