Drug Information

Drug General Information
Drug ID
D07ILP
Former ID
DNC000028
Drug Name
10-hydroxycamptothecin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538086]
Structure
Download
2D MOL

3D MOL
Formula
C20H16N2O5
Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)<br />O
InChI
1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChIKey
HAWSQZCWOQZXHI-FQEVSTJZSA-N
PubChem Compound ID
97226
PubChem Substance ID
407052, 645392, 8140019, 10228777, 11342034, 11362217, 11364533, 11367095, 11369657, 11372600, 11375589, 11377819, 11404568, 11485555, 11487619, 11489476, 11491436, 11493629, 11495453, 12015125, 12173672, 16124509, 26612627, 26680421, 26750003, 26758893, 44427566, 47348452, 48392929, 49831587, 50028362, 50107786, 50122774, 53787862, 53790463, 57336414, 80013607, 81093235, 85788508, 89360248, 92721280, 96024160, 103071286, 103082955, 103170545, 103922002, 104420324, 117586316, 124636619, 124891994
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inhibitor [538086]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 538086Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways. Int J Oncol. 1998 Apr;12(4):793-804.
Ref 538086Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways. Int J Oncol. 1998 Apr;12(4):793-804.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.