Drug General Information
Drug ID	D07JAG
Former ID	DIB008103
Drug Name	ABT-494
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Phase 2	[525096]
Company	Abbvie
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	JAK1	Target Info	Modulator	[532777]
KEGG Pathway	PI3K-Akt signaling pathway
	Osteoclast differentiation
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Hepatitis C
	Hepatitis B
	Measles
	Influenza A
	HTLV-I infection
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Pancreatic cancer
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
Pathway Interaction Database	p73 transcription factor network
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by TCPTP
	SHP2 signaling
	IL2-mediated signaling events
	IL2 signaling events mediated by PI3K
	IFN-gamma pathway
	IL6-mediated signaling events
	PDGFR-alpha signaling pathway
	IL2 signaling events mediated by STAT5
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	ISG15 antiviral mechanism
	Interleukin-7 signaling
	G beta:gamma signalling through PI3Kgamma
	Interleukin-2 signaling
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interferon alpha/beta signaling
	Interleukin receptor SHC signaling
	Regulation of IFNA signaling
WikiPathways	Type II interferon signaling (IFNG)
	Interferon type I signaling pathways
	TGF Beta Signaling Pathway
	IL-2 Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
	IL-3 Signaling Pathway
	Interleukin-2 signaling
	Interleukin-7 signaling
	JAK/STAT
	PDGF Pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	Prostate Cancer
	TSLP Signaling Pathway
	IL-9 Signaling Pathway
	Type III interferon signaling
	IL17 signaling pathway
	IL-7 Signaling Pathway
	Leptin signaling pathway
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Interferon alpha/beta signaling
	IL-5 Signaling Pathway
References
Ref 525096	ClinicalTrials.gov (NCT02365649) A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of ABT-494 for the Induction of Symptomatic and Endoscopic Remission in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Anti-TNF Therapy (Celest Study). U.S. National Institutes of Health.
Ref 532777	Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.

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