Drug Information

Drug General Information
Drug ID
D07JAN
Former ID
DIB020928
Drug Name
SCH 206272
Synonyms
SCH-206272
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539334]
Structure
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2D MOL

3D MOL
Formula
C33H41Cl4N5O4
InChI
InChI=1S/C33H41Cl4N5O4/c1-38-31(43)18-22-5-4-11-42(33(22)45)26-8-12-41(13-9-26)14-10-27(21-6-7-28(36)29(37)17-21)30(39-46-3)20-40(2)32(44)23-15-24(34)19-25(35)16-23/h6-7,15-17,19,22,26-27H,4-5,8-14,18,20H2,1-3H3,(H,38,43)/b39-30+/t22-,27-/m1/s1
InChIKey
UITMLIVWRRGLLR-SUFYPKAWSA-N
PubChem Compound ID
9875034
PubChem Substance ID
14839982, 24164411, 45622010, 78024158, 103277455, 104010356, 137104998, 229133044
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [526412]
NK-2 receptor Target Info Antagonist [526412]
Substance-P receptor Target Info Antagonist [526412]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
GPCR downstream signaling
References
Ref 539334(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2106).
Ref 526412SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol. 2002 Aug 23;450(2):191-202.

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