Drug General Information
Drug ID	D07JRA
Former ID	DNC006427
Drug Name	3-isopropyl-4-phenylnaphthalene-1,2-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527986]
Structure		Download 2D MOL 3D MOL
Formula	C19H16O2
Canonical SMILES	CC(C)C1=C(C2=CC=CC=C2C(=O)C1=O)C3=CC=CC=C3
InChI	1S/C19H16O2/c1-12(2)16-17(13-8-4-3-5-9-13)14-10-6-7-11-15(14)18(20)19(16)21/h3-12H,1-2H3
InChIKey	ZMFOKOSZYNMITK-UHFFFAOYSA-N
PubChem Compound ID	44409685
Target and Pathway
Target(s)	M-phase inducer phosphatase 1	Target Info	Inhibitor	[527986]
	M-phase inducer phosphatase 2	Target Info	Inhibitor	[527986]
KEGG Pathway	Cell cycle
	Progesterone-mediated oocyte maturation
	MicroRNAs in cancerhsa04010:MAPK signaling pathway
	MicroRNAs in cancer
NetPath Pathway	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Wnt Signaling Pathway
Pathway Interaction Database	E2F transcription factor network
	ATR signaling pathway
	Validated targets of C-MYC transcriptional activation
	ATM pathwayplk1_pathway:PLK1 signaling events
	FOXM1 transcription factor network
	p38 signaling mediated by MAPKAP kinases
	Aurora A signaling
Reactome	E2F mediated regulation of DNA replication
	G0 and Early G1
	Polo-like kinase mediated events
	Cyclin B2 mediated events
	Activation of ATR in response to replication stress
	Cyclin E associated events during G1/S transition
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Cyclin A:Cdk2-associated events at S phase entryR-HSA-157881:Cyclin B2 mediated events
	Cyclin A:Cdk2-associated events at S phase entry
WikiPathways	DNA Damage Response
	G1 to S cell cycle control
	S Phase
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Mitotic G1-G1/S phases
	Cell Cycle
	Cell Cycle Checkpoints
	miRNAs involved in DNA damage response
	miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
	MAPK Signaling Pathway
	Mitotic G2-G2/M phases
References
Ref 527986	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 527986	Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

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