Drug Information

Drug General Information
Drug ID
D07KBJ
Former ID
DIB016333
Drug Name
Renin inhibitors
Synonyms
Renin inhibitors (hypertension); Protease inhibitors (hypertension), Medivir; Renin inhibitors (hypertension), Medivir
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Investigative [552086]
Company
Medivir AB
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@@H](NC(=O)[C@@H](C[C@@H]([C@@H](N)COCc1ccc(c(c1)OCCC<br />OC)c1ccc(cc1)F)O)C(C)C)(C(=O)NCc1ccc(cc1)F)[C@@H](C)CC
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [543623]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 552086Design and synthesis of potent macrocyclic renin inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):358-62
Ref 543623(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2413).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.