Drug Information

Drug General Information
Drug ID
D07KYZ
Former ID
DIB004419
Drug Name
GABA-B receptor PAM
Synonyms
ADX-1; ADX-1a; ADX-1b; ADX-71441; ADX-1 program (GABA b positive allosteric modulators), Addex; GABA-B receptor PAM (pain/fragile X syndrome/urinary incontinence/GERD); GABA-B receptor PAM (pain/fragile X syndrome/urinary incontinence/GERD), Addex
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Investigative [543621]
Company
Addex Pharmaceuticals SA
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Modulator [543621]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 543621(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 241).
Ref 543621(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 241).

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