Drug Information

Drug General Information
Drug ID
D07MHL
Former ID
DIB018979
Drug Name
biphenylindanone A
Synonyms
LS-193,571
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540576]
Structure
Download
2D MOL
Formula
C30H30O4
InChI
InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
InChIKey
KMKBEESNZAPKMP-UHFFFAOYSA-N
PubChem Compound ID
9868580
PubChem Substance ID
14833499, 24159902, 45290844, 50076802, 76686186, 99431595, 103719771, 124772090, 125085357, 135723809, 137126808, 138769784, 141933486, 152090488, 162011578, 162249053, 170481120, 172652398, 174531074, 178100781, 184828630, 223258906, 223683565, 225361149, 228566257, 242059858, 244519943, 252157740, 252160327, 252214997
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [527661]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 540576(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3954).
Ref 527661Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4354-8.

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