Drug General Information
Drug ID	D07OCC
Former ID	DIB009936
Drug Name	JSM-10292
Synonyms	Bradykinin B2 receptor antagonist (pain/inflammation), Jerini
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[548330]
Company	Jerini AG
Structure		Download 2D MOL 3D MOL
Formula	C28H24F3N5O2
Canonical SMILES	c1(=O)c(cccn1Cc1c(c(ccn1)C)COc1cccc2c(cc(nc12)C)c1[nH]n<br />cc1C)C(F)(F)F
PubChem Compound ID	25019714
Target and Pathway
Target(s)	B2 bradykinin receptor	Target Info	Antagonist	[531929]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Inflammatory mediator regulation of TRP channels
	Regulation of actin cytoskeleton
	Endocrine and other factor-regulated calcium reabsorption
	Chagas disease (American trypanosomiasis)
	Pathways in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database	Direct p53 effectors
	Validated transcriptional targets of deltaNp63 isoforms
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (i) signalling events
WikiPathways	ACE Inhibitor Pathway
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Nifedipine Activity
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548330	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024715)
Ref 531929	Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist. Br J Pharmacol. 2012 Oct;167(4):839-53.

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