Drug Information

Drug General Information
Drug ID
D07OFM
Former ID
DNCL003593
Drug Name
GSK525762
Synonyms
GSK-525762
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [531179], [531260], [542051]
Company
GlaxoSmithKline
Structure
Download
2D MOL
Formula
C22H22ClN5O2
InChI
InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
InChIKey
AAAQFGUYHFJNHI-SFHVURJKSA-N
PubChem Compound ID
46943432
PubChem Substance ID
99455762, 104248639, 123047633, 124361310, 126718949, 136969525, 152258429, 160647265, 163685615, 170483631, 174007117, 175608105, 178103612, 185975563, 208012435, 210024094, 224616964, 226088051, 228042215, 242585542, 251910658, 251963077, 252164780, 252300198, 252445029, 252450347, 252553986
Target and Pathway
Target(s) Bromodomain-containing protein 4 Target Info Modulator
WikiPathways Chemical Compounds to monitor Proteins
References
Ref 531179Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
Ref 531260Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23.
Ref 542051(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7033).

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