TTD | Drug: D07PLK

Drug General Information
Drug ID	D07PLK
Former ID	DIB016402
Drug Name	WIN-64821
Synonyms	Q-20547A
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[546013]
Company	Sterling Winthrop Products Inc
Structure		Download 2D MOL 3D MOL
Formula	C40H36N6O4
Canonical SMILES	[C@]12([C@]34[C@@H](N5[C@@H](C4)C(=O)N[C@H](C5=O)Cc4ccc<br />cc4)Nc4c3cccc4)[C@@H](N3[C@@H](C2)C(=O)N[C@H](C3=O)Cc2c<br />cccc2)Nc2c1cccc2
CAS Number	CAS 150881-27-9
PubChem Compound ID	158365
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[533611]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546013	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005879)
Ref 533611	WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. II. Biological activity. J Antibiot (Tokyo). 1994 Apr;47(4):399-410.

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Drug Information