Drug Information

Drug General Information
Drug ID
D07PRH
Former ID
DIB001271
Drug Name
DE-098
Synonyms
ARG-098; Anti-Fas antibody, Santen; Anti-APO-1 antibody, Santen
Drug Type
Antibody
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 2 [547480]
Company
Centocor Ortho Biotech Inc
Target and Pathway
Target(s) CD95 Target Info [550368]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
p53 signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Alzheimer's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Pathways in cancer
Proteoglycans in cancer
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
FAS signaling pathway
p53 pathway
Pathway Interaction Database p73 transcription factor network
FAS (CD95) signaling pathway
Direct p53 effectors
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Validated transcriptional targets of TAp63 isoforms
Reactome FasL/ CD95L signaling
WikiPathways DNA Damage Response
TCR Signaling Pathway
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Apoptosis
Integrated Pancreatic Cancer Pathway
Adipogenesis
Allograft Rejection
Alzheimers Disease
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage Response
References
Ref 547480Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016731)
Ref 550368ARG098, a novel anti-human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient-HuRAg mouse model. BMC Musculoskeletal Disorders 2010,11:221.

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