Drug Information

Drug General Information
Drug ID
D07PYR
Former ID
DIB020776
Drug Name
pterostilbene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539747]
Structure
Download
2D MOL
Formula
C16H16O3
InChI
InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChIKey
VLEUZFDZJKSGMX-ONEGZZNKSA-N
PubChem Compound ID
5281727
PubChem Substance ID
12473, 486766, 8616747, 12015690, 14798822, 24724573, 26657958, 26719768, 26759346, 39315341, 46386623, 47359680, 47509826, 50125420, 53757155, 53787588, 56312441, 56313494, 57358338, 57389464, 61013506, 74382048, 87225412, 88529866, 92308260, 92721406, 93375057, 103291397, 104022800, 104826074, 113855784, 118845193, 124659002, 124812965, 125307610, 126619185, 126660095, 126661713, 131317937, 134343766, 135114939, 135371714, 135610176, 135650865, 136376470, 137026810, 137169343, 142181328, 144089127, 162063211
Target and Pathway
Target(s) Peroxisome proliferator activated receptor alpha Target Info Agonist [543889]
KEGG Pathway PPAR signaling pathway
cAMP signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Circadian Clock
Nuclear Receptors
References
Ref 539747(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2681).
Ref 543889(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 593).

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