Drug General Information
Drug ID	D07QMC
Former ID	DNC003626
Drug Name	3-Benzimidazol-2-ylhydroquinolin-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529891]
Structure		Download 2D MOL 3D MOL
Formula	C16H11N3O
Canonical SMILES	C1=CC=C2C(=C1)NC(=C3C=C4C=CC=CC4=NC3=O)N2
InChI	1S/C16H11N3O/c20-16-11(9-10-5-1-2-6-12(10)19-16)15-17-13-7-3-4-8-14(13)18-15/h1-9,17-18H
InChIKey	VAAMBTAFTGILMX-UHFFFAOYSA-N
PubChem Compound ID	5329370
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[529891]
	Beta platelet-derived growth factor receptor	Target Info	Inhibitor	[529891]
	Basic fibroblast growth factor receptor 1	Target Info	Inhibitor	[529891]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Proteoglycans in cancerhsa04010:MAPK signaling pathway
	Calcium signaling pathway
	Gap junction
	Regulation of actin cytoskeleton
	HTLV-I infection
	Pathways in cancer
	MicroRNAs in cancer
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04010:MAPK signaling pathway
	Adherens junction
	Signaling pathways regulating pluripotency of stem cells
	Proteoglycans in cancer
NetPath Pathway	IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathwayP00005:Angiogenesis
	PDGF signaling pathwayP00005:Angiogenesis
	FGF signaling pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networkptp1bpathway:Signaling events mediated by PTP1B
	S1P3 pathway
	Nectin adhesion pathway
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	PDGFR-beta signaling pathway
	Validated targets of C-MYC transcriptional repression
	PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
	Syndecan-4-mediated signaling events
	N-cadherin signaling events
	FGF signaling pathway
Reactome	Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferationR-HSA-1257604:PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascade
WikiPathways	Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Signaling by VEGF
	AngiogenesisWP51:Regulation of Actin Cytoskeleton
	MAPK Signaling Pathway
	Osteoblast Signaling
	PIP3 activates AKT signaling
	PDGF Pathway
	Signaling Pathways in Glioblastoma
	Signaling by PDGFWP51:Regulation of Actin Cytoskeleton
	Endochondral Ossification
	Mesodermal Commitment Pathway
	Hair Follicle Development: Induction (Part 1 of 3)
	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	Signaling by FGFR
References
Ref 529891	J Med Chem. 2009 Jan 22;52(2):278-92.Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.
Ref 529891	J Med Chem. 2009 Jan 22;52(2):278-92.Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.

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