Drug General Information
Drug ID	D07QSA
Former ID	DIB010961
Drug Name	CP-83101
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[544592]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Formula	C22H24O4
Canonical SMILES	C(=C/C=C/[C@@H](C[C@@H](CC(=O)OC)O)O)(c1ccccc1)c1ccccc1
CAS Number	CAS 120360-17-0
PubChem Compound ID	6438614
Target and Pathway
Target(s)	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Target Info	Inhibitor	[532476]
BioCyc Pathway	Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	Superpathway of cholesterol biosynthesis
	Mevalonate pathway
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	AMPK signaling pathway
	Bile secretion
NetPath Pathway	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	TSH Signaling Pathway
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBF and miR33 in cholesterol and lipid homeostasis
	Integrated Breast Cancer Pathway
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 544592	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000245)
Ref 532476	Efficacy, tissue distribution and biliary excretion of methyl (3R*,5S*)-(E)-3,5-dihydroxy-9,9-diphenyl-6,8-nonadienoate (CP-83101), a hepatoselective inhibitor of HMG-CoA reductase activity in the rat. Biochem Pharmacol. 1990 Sep 15;40(6):1281-93.

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