Drug Information

Drug General Information
Drug ID
D07QVY
Former ID
DIB013511
Drug Name
DBT-066
Synonyms
RAGE modulator (dementia), Digital Biotech
Indication Dementia [ICD9: 290-294; ICD10:F01-F07] Investigative [543730]
Company
Seoul National University
Target and Pathway
Target(s) Advanced glycosylation end product-specific receptor Target Info Modulator [543730]
Pathway Interaction Database amb2 Integrin signaling
Reactome RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Cytosolic sensors of pathogen-associated DNA
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
AGE/RAGE pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Advanced glycosylation endproduct receptor signaling
References
Ref 543730(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2843).
Ref 543730(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2843).

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