Drug General Information
Drug ID	D07RDG
Former ID	DNCL003318
Drug Name	AMG 416
Indication	Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46]		Phase 3	[548996]
Company	Amgen
Structure		Download 2D MOL
Formula	C38H74ClN21O10S2
PubChem Compound ID	71719617
Target and Pathway
Target(s)	Extracellular calcium-sensing receptor	Target Info	Modulator	[532354]
Pathway Interaction Database	E-cadherin signaling in keratinocytes
Reactome	G alpha (q) signalling events
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548996	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031284)
Ref 532354	Pharmacology of AMG 416 (Velcalcetide), a novel peptide agonist of the calcium-sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients. J Pharmacol Exp Ther. 2013 Aug;346(2):229-40.

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