Drug Information

Drug General Information
Drug ID
D07RYX
Former ID
DIB009479
Drug Name
Antide
Synonyms
GnRH antagonist, Serono; GnRHA, Serono; Iturelix nanospheres, Serono; ORF-23541; Iturelix (nanospheres encapsulated), Serono; Nal-Lys-GnRH
Drug Type
Small molecular drug
Indication Prostate hyperplasia [ICD10:N40] Discontinued in Phase 2 [540520], [544731]
Company
Merck Serono SA
Structure
Download
2D MOL

3D MOL
Formula
C82H108ClN17O14
InChI
InChI=1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)/t52-,62+,63-,64+,65+,66-,67-,68-,69+,70+/m1/s1
InChIKey
QRYFGTULTGLGHU-NBERXCRTSA-N
CAS Number
CAS 112568-12-4
PubChem Compound ID
16130938
PubChem Substance ID
12014319, 14817536, 14842256, 28730313, 40664625, 49865672, 53788136, 57379977, 93374735, 126665103, 135066444, 137267570, 139292358, 142991667, 152035442, 162182986, 164814858, 178100693, 184545257, 198965351, 223655172, 227838668, 247937378, 252211891, 252359081
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [528803]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540520(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3854).
Ref 544731Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000763)
Ref 528803Antide (Nal-Lys GnRH antagonist) suppression of pituitary-testicular function and sexual behavior in group-living rhesus monkeys. Physiol Behav. 1991 Aug;50(2):429-35.

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