Drug Information

Drug General Information
Drug ID
D07SXO
Former ID
DIB000633
Drug Name
AG-041R
Drug Type
Small molecular drug
Indication Ulcerative colitis [ICD9: 556; ICD10:K51] Terminated [543292], [545856]
Company
Chugai Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C31H36N4O5
InChI
InChI=1S/C31H36N4O5/c1-5-39-28(40-6-2)20-35-26-10-8-7-9-25(26)31(29(35)37,19-27(36)32-23-15-11-21(3)12-16-23)34-30(38)33-24-17-13-22(4)14-18-24/h7-18,28H,5-6,19-20H2,1-4H3,(H,32,36)(H2,33,34,38)/t31-/m1/s1
InChIKey
KOLPMNSDISYEBU-WJOKGBTCSA-N
CAS Number
CAS 199800-49-2
PubChem Compound ID
9807431
PubChem Substance ID
14763571, 14910442, 24114824, 44843424, 49984816, 75106951, 134224405, 135649902, 137276069, 142279649, 143077868, 143218572, 163123051, 204380656, 223704995, 248620067
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Modulator [526056]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543292(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 901).
Ref 545856Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005071)
Ref 526056AG-041R, a gastrin/CCK-B antagonist, stimulates chondrocyte proliferation and metabolism in vitro. Biochem Biophys Res Commun. 2001 May 25;283(5):1118-23.

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