Drug Information

Drug General Information
Drug ID
D07TBD
Former ID
DIB013301
Drug Name
DT-2228
Synonyms
MGluR2 NAMs (Alzheimer's disease/depression), DomainTherapeutics; Metabotropic glutamate receptor 2 modulators (Alzheimer's disease/depression), DomainTherapeutics
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Investigative [543747]
Company
Domain Therapeutics SA
Structure
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2D MOL

3D MOL
Canonical SMILES
c1ccc2c(c1)/C(=N/O)/C1C(O2)(C1)C(=O)Nc1ccc(cc1)Cl
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator [543747]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 543747(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).
Ref 543747(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290).

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