Drug General Information
Drug ID
D07TNE
Former ID
DIB019942
Drug Name
GSK126
Synonyms
GSK 126; GSK-126
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532074]
Structure
Download
2D MOL
Formula
C31H38N6O2
InChI
InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1
InChIKey
FKSFKBQGSFSOSM-QFIPXVFZSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Enhancer of zeste homolog 2 Target Info Inhibitor [532010]
KEGG Pathway MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
Reactome PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
WikiPathways Interactome of polycomb repressive complex 2 (PRC2)
Endoderm Differentiation
Integrated Pancreatic Cancer Pathway
Histone Modifications
Cell Differentiation - meta
miRs in Muscle Cell Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 532074EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012 Dec 6;492(7427):108-12.
Ref 532010Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens. J Biomol Screen. 2012 Dec;17(10):1279-92.

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