Drug Information

Drug General Information
Drug ID
D07UYO
Former ID
DAP000398
Drug Name
Linezolid
Synonyms
Linezlid; ZLD; Zyvox; Zyvoxa; Zyvoxam; Zyvoxid; PNU 100766; U 100766; Linezolid & VRC3375; Linezolid [USAN:INN]; PNU-100766; U-100766; Zyvox (TN); Zyvoxam (TN); Zyvoxid (TN); NDA 21-130 Zyvox (linezolid tablets); NDA 21-131 Zyvox for injection (linezolid injection); NDA 21-132 Zyvox oral suspension (linzolid oral suspension); Linezolid (JAN/USAN/INN); PNU-100766, U-100766, Zyvoxid, Zyvoxam, Linezolid; N-((3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide; N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide; N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide; N-({5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide, N-[[(S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide; (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide; 111GE017
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [536773]
Therapeutic Class
Antibiotics
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C16H20FN3O4
Canonical SMILES
CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
InChI
1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChIKey
TYZROVQLWOKYKF-ZDUSSCGKSA-N
CAS Number
CAS 165800-03-3
PubChem Compound ID
441401
PubChem Substance ID
10346, 626285, 647772, 7848010, 7979777, 10298826, 11528778, 12014976, 12085958, 14753513, 14924659, 26719842, 36885243, 46386641, 46504452, 49681612, 49831260, 50087120, 53662306, 53777003, 57403668, 92308338, 92308882, 92714736, 93166562, 99431929, 99437138, 99445240, 103188044, 104009867, 104178938, 104625366, 118046801, 121360858, 124658996, 124757230, 124766233, 125164034, 126629440, 129334276, 131301211, 134224467, 134337694, 135610127, 135698276, 137001445, 137178947, 142376443, 144116144, 144205799
SuperDrug ATC ID
J01XX08
SuperDrug CAS ID
cas=165800033
Target and Pathway
Target(s) 23S rRNA Target Info Binder [537206]
References
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 537206Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23. Epub 2009 Apr 6.

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