Drug Information

Drug General Information
Drug ID
D07VXB
Former ID
DCL000803
Drug Name
FG-3019
Drug Type
Small molecular drug
Indication Type 2 diabetes; Idiopathic pulmonary fibrosis [ICD9: 250, 250.00, 250.02, 515, 516.3, 709.2; ICD10:E08-E13, E11, J84.1, L90.5] Phase 2 [536836]
Diabetic nephropathy [ICD9: 250.4; ICD10:E11.21] Phase 1b [536836]
Company
Fibrogen
Structure
Download
2D MOL

3D MOL
Formula
C24H25FN4O2
Canonical SMILES
CC1=CC=CN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)<br />F)C
InChI
1S/C24H25FN4O2/c1-15-4-3-10-29-23(15)26-16(2)19(24(29)30)9-13-28-11-7-17(8-12-28)22-20-6-5-18(25)14-21(20)31-27-22/h3-6,10,14,17H,7-9,11-13H2,1-2H3
InChIKey
ZZQNEJILGNNOEP-UHFFFAOYSA-N
PubChem Compound ID
71351
PubChem Substance ID
8194575, 14855963, 17396844, 43127690, 47583721, 48179710, 57318149, 75304817, 85209798, 103122825, 104350249, 117586339, 129978107, 134339281, 134339355, 135029360, 135650754, 136350834, 137243811, 137451010, 141726158, 160687115, 162309179, 162784444, 179149777, 198981439, 224994265, 226493643
Target and Pathway
Target(s) Connective tissue growth factor Target Info Inhibitor [536528]
KEGG Pathway Hippo signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database amb2 Integrin signaling
TGF-beta receptor signaling
Reactome PPARA activates gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
YAP1- and WWTR1 (TAZ)-stimulated gene expression
References
Ref 536836Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63.
Ref 536528Current and emerging drugs for idiopathic pulmonary fibrosis. Expert Opin Emerg Drugs. 2007 Nov;12(4):627-46.

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