Drug General Information
Drug ID	D07WLT
Former ID	DNC009636
Drug Name	6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529834]
Structure		Download 2D MOL 3D MOL
Formula	C15H13NO
Canonical SMILES	C1CC2=C(CC1=O)C=CC(=C2)C3=CN=CC=C3
InChI	1S/C15H13NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-4,7-8,10H,5-6,9H2
InChIKey	XMIVJNDWTQQRAQ-UHFFFAOYSA-N
PubChem Compound ID	25180108
Target and Pathway
Target(s)	Cytochrome P450 11B1, mitochondrial	Target Info	Inhibitor	[529834]
	Cytochrome P450 3A4	Target Info	Inhibitor	[529834]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Mineralocorticoid biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathwayshsa00140:Steroid hormone biosynthesis
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450
	Drug metabolism - other enzymes
	Metabolic pathways
	Bile secretion
	Chemical carcinogenesis
PathWhiz Pathway	SteroidogenesisPW000015:Caffeine Metabolism
	Retinol Metabolism
Reactome	Glucocorticoid biosynthesis
	Endogenous sterolsR-HSA-211981:Xenobiotics
	Aflatoxin activation and detoxification
WikiPathways	Metapathway biotransformation
	Oxidation by Cytochrome P450
	Metabolism of steroid hormones and vitamin D
	Corticotropin-releasing hormoneWP702:Metapathway biotransformation
	Aflatoxin B1 metabolism
	Estrogen metabolism
	Benzo(a)pyrene metabolism
	Tamoxifen metabolism
	Tryptophan metabolism
	Nuclear Receptors in Lipid Metabolism and Toxicity
	Nuclear Receptors Meta-Pathway
	Farnesoid X Receptor Pathway
	Vitamin D Receptor Pathway
	Felbamate Metabolism
	Lidocaine metabolism
	Nifedipine Activity
	Colchicine Metabolic Pathway
	Irinotecan Pathway
	Drug Induction of Bile Acid Pathway
	Fatty Acid Omega Oxidation
	Codeine and Morphine Metabolism
References
Ref 529834	J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Ref 529834	J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.