| Drug General Information |
| Drug ID |
D07WLT
|
| Former ID |
DNC009636
|
| Drug Name |
6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H13NO
|
| Canonical SMILES |
C1CC2=C(CC1=O)C=CC(=C2)C3=CN=CC=C3
|
| InChI |
1S/C15H13NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-4,7-8,10H,5-6,9H2
|
| InChIKey |
XMIVJNDWTQQRAQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Glucocorticoid biosynthesis
|
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Mineralocorticoid biosynthesis
|
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathwayshsa00140:Steroid hormone biosynthesis
|
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Linoleic acid metabolism
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Retinol metabolism
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Metabolism of xenobiotics by cytochrome P450
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Drug metabolism - cytochrome P450
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Drug metabolism - other enzymes
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Metabolic pathways
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Bile secretion
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Chemical carcinogenesis
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PathWhiz Pathway
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SteroidogenesisPW000015:Caffeine Metabolism
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Retinol Metabolism
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Reactome
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Glucocorticoid biosynthesis
|
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Endogenous sterolsR-HSA-211981:Xenobiotics
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Aflatoxin activation and detoxification
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WikiPathways
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Metapathway biotransformation
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Oxidation by Cytochrome P450
|
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Metabolism of steroid hormones and vitamin D
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Corticotropin-releasing hormoneWP702:Metapathway biotransformation
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Aflatoxin B1 metabolism
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Estrogen metabolism
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Benzo(a)pyrene metabolism
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Tamoxifen metabolism
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Tryptophan metabolism
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Nuclear Receptors in Lipid Metabolism and Toxicity
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Nuclear Receptors Meta-Pathway
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Farnesoid X Receptor Pathway
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Vitamin D Receptor Pathway
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Felbamate Metabolism
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Lidocaine metabolism
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Nifedipine Activity
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Colchicine Metabolic Pathway
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Irinotecan Pathway
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Drug Induction of Bile Acid Pathway
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Fatty Acid Omega Oxidation
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Codeine and Morphine Metabolism
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| References |
| REF 1 | J Med Chem. 2008 Dec 25;51(24):8077-87.In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. |
|---|
