Drug Information

Drug General Information
Drug ID
D07WXT
Former ID
DNC000879
Drug Name
Lithium chloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535388], [536546]
Structure
Download
2D MOL

3D MOL
Formula
ClLi
Canonical SMILES
[Li+].[Cl-]
InChI
1S/ClH.Li/h1H;/q;+1/p-1
InChIKey
KWGKDLIKAYFUFQ-UHFFFAOYSA-M
CAS Number
CAS 7447-41-8
PubChem Compound ID
433294
PubChem Substance ID
574598, 645372, 6117077, 10296192, 10534590, 11111379, 15066026, 17405166, 24278056, 24845370, 24852187, 24852673, 24858795, 24866862, 24868517, 24882223, 24882224, 24882225, 24882226, 24884921, 24886496, 24896448, 24896459, 29291114, 48243350, 48318401, 48423615, 49658753, 49855771, 50106409, 50106410, 50414734, 50414735, 53777710, 53790639, 56310984, 56311064, 56312344, 56313565, 56314428, 56369244, 57402806, 57651888, 57651889, 57651890, 57651891, 57652457, 83620214, 85087326, 85087327
ChEBI ID
ChEBI:48607
Target and Pathway
Target(s) Glycogen synthase kinase-3 Target Info Inhibitor [535388], [536546]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
References
Ref 535388Glycogen synthase kinase 3: an emerging therapeutic target. Trends Mol Med. 2002 Mar;8(3):126-32.
Ref 536546Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. J Neuroimmune Pharmacol. 2007 Mar;2(1):93-6. Epub 2006 Dec 16.
Ref 535388Glycogen synthase kinase 3: an emerging therapeutic target. Trends Mol Med. 2002 Mar;8(3):126-32.
Ref 536546Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. J Neuroimmune Pharmacol. 2007 Mar;2(1):93-6. Epub 2006 Dec 16.

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