Drug Information

Drug General Information
Drug ID
D07XPT
Former ID
DCL000630
Drug Name
Ronacaleret
Drug Type
Small molecular drug
Indication Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] Discontinued in Phase 2 [548261]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C25H31F2NO4
Canonical SMILES
CC(C)(CC1CC2=CC=CC=C2C1)NCC(COC3=C(C(=CC(=C3)CCC(=O)O)F<br />)F)O
InChI
1S/C25H31F2NO4/c1-25(2,13-17-9-18-5-3-4-6-19(18)10-17)28-14-20(29)15-32-22-12-16(7-8-23(30)31)11-21(26)24(22)27/h3-6,11-12,17,20,28-29H,7-10,13-15H2,1-2H3,(H,30,31)/t20-/m1/s1
InChIKey
FQJISUPNMFRIFZ-HXUWFJFHSA-N
PubChem Compound ID
10345214
PubChem Substance ID
24843560, 28671438, 33978265, 79161622, 131275772, 131348967, 134339166, 135262067, 137263923, 137475361, 198987907, 229727902, 245552472
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Antagonist [550963]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 548261Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023902)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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