Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07ZAJ
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| Former ID |
DIB020727
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| Drug Name |
PIP2
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| Synonyms |
PIP2; PIP2; phosphatidylinositol-4,5-bisphosphate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [539517] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C45H85O19P3
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| InChI |
InChI=1S/C45H85O19P3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(46)59-35-37(61-39(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)36-60-67(57,58)64-43-40(48)41(49)44(62-65(51,52)53)45(42(43)50)63-66(54,55)56/h17-20,37,40-45,48-50H,3-16,21-36H2,1-2H3,(H,57,58)(H2,51,52,53)(H2,54,55,56)/b19-17-,20-18-/t37-,40-,41+,42+,43-,44-,45-/m1/s1
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| InChIKey |
IGQSAMXNWMLOOS-GGDMTQDZSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Kir3.2 | Target Info | Activator | [534567] | |
| Potassium channel KCNJ3 Kir3.1 | Target Info | Activator | [534567] | ||
| Kir3.3 | Target Info | Activator | [534143] | ||
| Potassium voltage-gated channel subfamily KQT member 4 | Target Info | Activator | [527827] | ||
| TRPM7 | Target Info | Activator | [526311] | ||
| IP3R1 | Target Info | Antagonist | [543955] | ||
| PLD2 | Target Info | Activator | [534622] | ||
| Kir2.1 | Target Info | Activator | [525964] | ||
| ATP-sensitive K+ channel | Target Info | Activator | [534737] | ||
| HCN2 | Target Info | Activator | [528505] | ||
| TRPM4 | Target Info | Activator | [527762] | ||
| Potassium voltage-gated channel subfamily KQT member 2 | Target Info | Activator | [527827] | ||
| KEGG Pathway | Circadian entrainment | ||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Cholinergic synapse | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Estrogen signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Morphine addictionhsa04725:Cholinergic synapsehsa04713:Circadian entrainment | |||||
| Morphine addictionhsa04725:Cholinergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| GABA-B receptor II signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart ContractionPW000564:Muscle/Heart Contraction | ||||
| Reactome | Activation of G protein gated Potassium channels | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296041:Activation of G protein gated Potassium channels | |||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsR-HSA-1296072:Voltage gated Potassium channels | |||||
| Interaction between L1 and Ankyrins | |||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | ||||
| G Protein Signaling Pathways | |||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Potassium ChannelsWP2669:Potassium ChannelsWP536:Calcium Regulation in the Cardiac Cell | |||||
| Notch Signaling Pathway | |||||
| Potassium ChannelsWP2669:Potassium Channels | |||||
| L1CAM interactions | |||||
| References | |||||
| Ref 525964 | Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett. 2001 Feb 9;490(1-2):49-53. | ||||
| Ref 526311 | The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol. 2002 May;4(5):329-36. | ||||
| Ref 527762 | Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem. 2005 Nov 25;280(47):39185-92. Epub 2005 Sep 26. | ||||
| Ref 527827 | Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2005 Oct 26;25(43):9825-35. | ||||
| Ref 528505 | Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol. 2006 Nov;128(5):593-604. | ||||
| Ref 534143 | Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2. Science. 1996 Aug 16;273(5277):956-9. | ||||
| Ref 534567 | Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature. 1998 Feb 19;391(6669):803-6. | ||||
| Ref 534622 | Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol Chem. 1998 May 22;273(21):12846-52. | ||||
| Ref 534737 | PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science. 1998 Nov 6;282(5391):1141-4. | ||||
| Ref 543955 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743). | ||||
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