Drug Information

Drug General Information
Drug ID
D07ZCK
Former ID
DNC011521
Drug Name
ZK-93423
Drug Type
Small molecular drug
Indication Epileptic seizures [ICD9: 345.9, 780.3; ICD10:G40, P90, R56] Phase 3 [467683], [533661]
Structure
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2D MOL

3D MOL
Formula
C23H22N2O4
InChI
InChI=1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3
InChIKey
ALBKMJDFBZVHAK-UHFFFAOYSA-N
PubChem Compound ID
121926
PubChem Substance ID
7980912, 10239868, 14829922, 26755019, 29302418, 47434919, 47657169, 48179786, 48179787, 50070370, 50071017, 57339848, 80294733, 103825000, 103920823, 104414616, 117578843, 127422224, 134348726, 135076454, 136351139, 137010628, 160687891, 162224540, 177748540, 178101163, 179293780, 224986468, 232769861, 241147277
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [530319]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [530319]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [530319]
Gamma-aminobutyric acid receptor Target Info Inhibitor [530319]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467683(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4346).
Ref 533661Abecarnil enhances GABA-induced currents in acutely isolated cerebellar Purkinje cells. Neuropharmacology. 1995 Feb;34(2):157-63.
Ref 530319J Med Chem. 1990 Mar;33(3):1062-9.Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.

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