Drug Information

Drug General Information
Drug ID
D07ZTD
Former ID
DNCL001777
Drug Name
MB-07811
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Phase 2 [522631]
Company
Ligand Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C28H32ClO5P
Canonical SMILES
CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OCP3(=O)OCCC(O3)<br />C4=CC(=CC=C4)Cl
InChI
1S/C28H32ClO5P/c1-18(2)25-14-21(8-9-27(25)30)15-26-19(3)12-24(13-20(26)4)32-17-35(31)33-11-10-28(34-35)22-6-5-7-23(29)16-22/h5-9,12-14,16,18,28,30H,10-11,15,17H2,1-4H3/t28-,35?/m0/s1
InChIKey
LGGPZDRLTDGYSQ-GYKKGXIBSA-N
PubChem Compound ID
11998611
PubChem Substance ID
17497789, 24501070, 37446989, 78229339, 103583151, 104099052, 141232024, 229190343, 246013400
Target and Pathway
Target(s) Thyroid hormone receptor beta-1 Target Info Modulator [543886]
KEGG Pathway Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Nuclear Receptors
References
Ref 522631ClinicalTrials.gov (NCT00879112) Study of MB07811 in Subjects With Hypercholesterolemia. U.S. National Institutes of Health.
Ref 543886(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 589).

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