| Drug General Information |
| Drug ID |
D08BMM
|
| Former ID |
DNC003790
|
| Drug Name |
OROIDIN
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H11Br2N5O
|
| Canonical SMILES |
C1=C(NC(=C1Br)Br)C(=O)NCC=CC2=CN=C(N2)N
|
| InChI |
1S/C11H11Br2N5O/c12-7-4-8(18-9(7)13)10(19)15-3-1-2-6-5-16-11(14)17-6/h1-2,4-5,18H,3H2,(H,15,19)(H3,14,16,17)/b2-1+
|
| InChIKey |
QKJAXHBFQSBDAR-OWOJBTEDSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Dual specificity mitogen-activated protein kinase kinase 1 |
Target Info |
Inhibitor |
[2]
|
|---|
| Enoyl-ACP reductase |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
|
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Ras signaling pathway
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Rap1 signaling pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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HIF-1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Oocyte meiosis
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PI3K-Akt signaling pathway
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Vascular smooth muscle contraction
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Dorso-ventral axis formation
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VEGF signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Gap junction
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Signaling pathways regulating pluripotency of stem cells
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Toll-like receptor signaling pathway
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Natural killer cell mediated cytotoxicity
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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TNF signaling pathway
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Long-term potentiation
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Neurotrophin signaling pathway
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Cholinergic synapse
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Serotonergic synapse
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Long-term depression
|
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Regulation of actin cytoskeleton
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Insulin signaling pathway
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Estrogen signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Prion diseases
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Alcoholism
|
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Hepatitis B
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Influenza A
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Pathways in cancer
|
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Proteoglycans in cancer
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MicroRNAs in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
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Glioma
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Prostate cancer
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Thyroid cancer
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Non-small cell lung cancer
|
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Central carbon metabolism in cancer
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Choline metabolism in cancer
|
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NetPath Pathway
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FSH Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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B cell activation
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
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Integrin signalling pathway
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PDGF signaling pathway
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T cell activation
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Toll receptor signaling pathway
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VEGF signaling pathway
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Ras Pathway
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
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CCKR signaling map ST
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Pathway Interaction Database
|
Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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GMCSF-mediated signaling events
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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EPHB forward signaling
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SHP2 signaling
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Netrin-mediated signaling events
|
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mTOR signaling pathway
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Class IB PI3K non-lipid kinase events
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IL2-mediated signaling events
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Ras signaling in the CD4+ TCR pathway
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Ceramide signaling pathway
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IFN-gamma pathway
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ErbB1 downstream signaling
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ErbB2/ErbB3 signaling events
|
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FOXM1 transcription factor network
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PDGFR-beta signaling pathway
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Neurotrophic factor-mediated Trk receptor signaling
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Nongenotropic Androgen signaling
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Hedgehog signaling events mediated by Gli proteins
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CXCR3-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Signaling events mediated by VEGFR1 and VEGFR2
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Cellular roles of Anthrax toxin
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Trk receptor signaling mediated by the MAPK pathway
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Downstream signaling in naï
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Signaling events mediated by focal adhesion kinase
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Insulin Signalling
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Reactome
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MAPK3 (ERK1) activation
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Uptake and function of anthrax toxins
|
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RAF activation
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MAP2K and MAPK activation
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Negative feedback regulation of MAPK pathway
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MAP3K8 (TPL2)-dependent MAPK1/3 activation
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WikiPathways
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Toll-like receptor signaling pathway
|
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Serotonin Receptor 4/6/7 and NR3C Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Serotonin HTR1 Group and FOS Pathway
|
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Estrogen signaling pathway
|
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TCR Signaling Pathway
|
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ErbB Signaling Pathway
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Hypothetical Network for Drug Addiction
|
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Senescence and Autophagy in Cancer
|
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EPO Receptor Signaling
|
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Regulation of Actin Cytoskeleton
|
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IL-2 Signaling Pathway
|
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Insulin Signaling
|
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EGF/EGFR Signaling Pathway
|
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MAPK Cascade
|
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MAPK Signaling Pathway
|
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TGF beta Signaling Pathway
|
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IL-6 signaling pathway
|
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Signaling of Hepatocyte Growth Factor Receptor
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Focal Adhesion
|
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Kit receptor signaling pathway
|
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IL-3 Signaling Pathway
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Bladder Cancer
|
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Cardiac Hypertrophic Response
|
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MAP kinase activation in TLR cascade
|
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RAF/MAP kinase cascade
|
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Nanoparticle-mediated activation of receptor signaling
|
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Structural Pathway of Interleukin 1 (IL-1)
|
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Genes and (Common) Pathways Underlying Drug Addiction
|
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Nifedipine Activity
|
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Aryl Hydrocarbon Receptor
|
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PDGF Pathway
|
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BDNF signaling pathway
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Corticotropin-releasing hormone
|
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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B Cell Receptor Signaling Pathway
|
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Prostate Cancer
|
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Signaling Pathways in Glioblastoma
|
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TSLP Signaling Pathway
|
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IL-9 Signaling Pathway
|
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Endothelin Pathways
|
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IL-7 Signaling Pathway
|
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Leptin signaling pathway
|
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TSH signaling pathway
|
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RANKL/RANK Signaling Pathway
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IL-1 signaling pathway
|
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Signaling by FGFR
|
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Integrin-mediated Cell Adhesion
|
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L1CAM interactions
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Regulation of toll-like receptor signaling pathway
|
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Osteopontin Signaling
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | Bioorg Med Chem. 2007 Nov 1;15(21):6834-45. Epub 2007 Aug 22.Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. |
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| REF 2 | J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). |
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