Drug Information

Drug General Information
Drug ID
D08BXD
Former ID
DIB018625
Drug Name
4-MPPTS
Synonyms
LY487379; LY-487379
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538879]
Structure
Download
2D MOL
Formula
C21H19F3N2O4S
InChI
InChI=1S/C21H19F3N2O4S/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24/h2-13H,14-15H2,1H3
InChIKey
ALMACYDZFBMGOR-UHFFFAOYSA-N
PubChem Compound ID
9825084
PubChem Substance ID
14784230, 24127745, 44923222, 50074799, 74504595, 99431556, 103330336, 104021920, 125645291, 131311711, 135649803, 142987844, 143292860, 162222462, 163422498, 163852769, 172874219, 223535522, 223845013, 225355768, 229789778, 241072313, 244253016
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [527079]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538879(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1402).
Ref 527079SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3099-102.

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