Drug General Information
Drug ID	D08CVQ
Former ID	DCL001053
Drug Name	Mipomersen
Drug Type	Antisense drug
Indication	Familial hypercholesterolemia [ICD9: 272; ICD10:E78.0]		Approved	[532193], [532651], [542386]
Therapeutic Class	Antisense
Company	Isis Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C230H305N67O122P19S19-19
InChIKey	TZRFSLHOCZEXCC-HIVFKXHNSA-A
CAS Number	CAS 1000120-98-8
PubChem Compound ID	71301230
PubChem Substance ID	135264286, 178103936
Target and Pathway
Target(s)	mRNA of human apolipoprotein B	Target Info		[551023]
KEGG Pathway	Fat digestion and absorption
	Vitamin digestion and absorption
Pathway Interaction Database	amb2 Integrin signaling
	FOXA1 transcription factor network
Reactome	LDL-mediated lipid transport
	Chylomicron-mediated lipid transport
	Cell surface interactions at the vascular wall
	Scavenging by Class B Receptors
	Scavenging by Class A Receptors
	Scavenging by Class H Receptors
	Platelet sensitization by LDL
	Retinoid metabolism and transport
WikiPathways	Statin Pathway
	Binding and Uptake of Ligands by Scavenger Receptors
	Visual phototransduction
	Lipid digestion, mobilization, and transport
	Platelet homeostasis
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 532193	Apolipoprotein B antisense inhibition--update on mipomersen. Curr Pharm Des. 2013;19(17):3132-42.
Ref 532651	2013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.
Ref 542386	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7364).
Ref 551023	Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.

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