Drug General Information
Drug ID
Former ID
Drug Name
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526355]


Canonical SMILES
CS(=O)C1=CC=C(C=C1)CSC2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=<br />C4)F
PubChem Compound ID
Target and Pathway
Target(s) Cytochrome P450 3A4 Target Info Inhibitor [526668]
Mitogen-activated protein kinase 11 Target Info Inhibitor [526355]
Mitogen-activated protein kinase 14 Target Info Inhibitor [526355]
Cytochrome P450 2D6 Target Info Inhibitor [526668]
MAP kinase p38 Target Info Inhibitor [526355]
KEGG Pathway Steroid hormone biosynthesis
Linoleic acid metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Bile secretion
Chemical carcinogenesishsa04010:MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Salmonella infection
Chagas disease (American trypanosomiasis)
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Proteoglycans in cancerhsa00980:Metabolism of xenobiotics by cytochrome P450
Serotonergic synapsehsa04010:MAPK signaling pathway
Oocyte meiosis
Proteoglycans in cancer
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
TGF-beta signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
Parkinson disease
Toll receptor signaling pathway
VEGF signaling pathway
p38 MAPK pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Pathway Interaction Database p73 transcription factor network
p38 MAPK signaling pathway
Plasma membrane estrogen receptor signaling
CD40/CD40L signaling
Regulation of p38-alpha and p38-beta
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
Rapid glucocorticoid signaling
ATF-2 transcription factor network
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
Signaling events mediated by VEGFR1 and VEGFR2
VEGFR3 signaling in lymphatic endothelium
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
BCR signaling pathway
Atypical NF-kappaB pathway
IL4-mediated signaling events
IL12-mediated signaling events
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of Androgen receptor activity
Retinoic acid receptors-mediated signaling
EPO signaling pathway
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinrhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-delta
PathWhiz Pathway Caffeine Metabolism
Retinol MetabolismPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Xenobiotics
Aflatoxin activation and detoxificationR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-211981:XenobioticsR-HSA-168638:NOD1/2 Signaling Pathway
WikiPathways Metapathway biotransformation
Aflatoxin B1 metabolism
Estrogen metabolism
Benzo(a)pyrene metabolism
Tamoxifen metabolism
Tryptophan metabolism
Oxidation by Cytochrome P450
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Vitamin D Receptor Pathway
Felbamate Metabolism
Lidocaine metabolism
Nifedipine Activity
Colchicine Metabolic Pathway
Irinotecan Pathway
Drug Induction of Bile Acid Pathway
Fatty Acid Omega Oxidation
Codeine and Morphine MetabolismWP75:Toll-like receptor signaling pathway
Insulin Signaling
IL-4 Signaling Pathway
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Parkinsons Disease Pathway
NGF signalling via TRKA from the plasma membrane
DSCAM interactions
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
EGF/EGFR Signaling Pathway
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Kit receptor signaling pathway
Cardiac Hypertrophic Response
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Cardiac Progenitor Differentiation
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
MicroRNAs in cardiomyocyte hypertrophy
Regulation of toll-like receptor signaling pathwayWP702:Metapathway biotransformation
Aripiprazole Metabolic Pathway
Signal Transduction of S1P Receptor
Integrin-mediated Cell Adhesion
Regulation of toll-like receptor signaling pathway
Ref 526355J Med Chem. 2002 Jun 20;45(13):2733-40.From imidazoles to pyrimidines: new inhibitors of cytokine release.
Ref 526355J Med Chem. 2002 Jun 20;45(13):2733-40.From imidazoles to pyrimidines: new inhibitors of cytokine release.
Ref 526668J Med Chem. 2003 Jul 17;46(15):3230-44.Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.

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