Drug Information

Drug General Information
Drug ID
D08EFL
Former ID
DNCL002720
Drug Name
Pancreatic cancer vaccine
Synonyms
GVAX (TN)
Drug Type
Vaccine
Indication Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10:C25] Phase 2 [550207]
Company
BioSante Pharmaceuticals; Aduro BioTech
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor receptor alpha chain Target Info [527643]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway IL3 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Alpha9 beta1 integrin signaling events
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Surfactant metabolism
Interleukin receptor SHC signaling
WikiPathways Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 550207Clinical pipeline report, company report or official report of Aduro.
Ref 527643Vaccines in cancer: GVAX, a GM-CSF gene vaccine. Expert Rev Vaccines. 2005 Jun;4(3):259-74.

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