Drug Information

Drug General Information
Drug ID
D08ESA
Former ID
DIB006395
Drug Name
CI-966
Synonyms
1-[2-[Bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
Drug Type
Small molecular drug
Indication Convulsions [ICD9: 780.3; ICD10:R56.0] Phase 1 [467852], [533771]
Structure
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2D MOL

3D MOL
Formula
C23H21F6NO3
InChI
InChI=1S/C23H21F6NO3/c24-22(25,26)18-7-3-15(4-8-18)20(16-5-9-19(10-6-16)23(27,28)29)33-13-12-30-11-1-2-17(14-30)21(31)32/h2-10,20H,1,11-14H2,(H,31,32)
InChIKey
CMHQDSBIBSKHFP-UHFFFAOYSA-N
PubChem Compound ID
198693
PubChem Substance ID
5713134, 7978936, 10262983, 11114017, 15479394, 33518343, 79088244, 85789019, 103276824, 103917586, 103946489, 113468361, 125659071, 131294429, 135227789, 162365020, 162475412, 172657830, 178101332, 198975784, 215779616, 223554371, 233486068, 252325762
Target and Pathway
Target(s) Sodium- and chloride-dependent GABA transporter 1 Target Info Modulator [533771]
KEGG Pathway GABAergic synapse
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
References
Ref 467852(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4612).
Ref 533771Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
Ref 533771Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

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