Drug Information
Drug General Information | |||||
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Drug ID |
D08FOT
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Former ID |
DNC009736
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Drug Name |
PSB-1115
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
Download2D MOL |
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Formula |
C14H14N4O5S
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InChI |
InChI=1S/C14H14N4O5S/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23)
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InChIKey |
UYDRRQPGDSIMNU-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Adenosine A2b receptor | Target Info | Inhibitor | [2] | |
Adenosine A1 receptor | Target Info | Inhibitor | [2] | ||
KEGG Pathway | Rap1 signaling pathway | ||||
Calcium signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Vascular smooth muscle contraction | |||||
Alcoholismhsa04022:cGMP-PKG signaling pathway | |||||
cAMP signaling pathway | |||||
Sphingolipid signaling pathway | |||||
Morphine addiction | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway | |||||
RANKL Signaling Pathway | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Pathway Interaction Database | C-MYB transcription factor network | ||||
PathWhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | ||||
Reactome | Adenosine P1 receptors | ||||
G alpha (s) signalling events | |||||
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors | |||||
G alpha (i) signalling events | |||||
WikiPathways | Nucleotide GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP80:Nucleotide GPCRs | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3286). | ||||
REF 2 | J Med Chem. 2009 Jul 9;52(13):3994-4006.1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. | ||||
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