Drug Information

Drug General Information
Drug ID
D08GYO
Former ID
DAP000986
Drug Name
Procarbazine
Synonyms
Ibenzmethyzin; Ibenzmethyzine; MBH; MIH; Natulan; Natulanar; PCX; Procarbazin; Procarbazina; Procarbazinum; Procarbazin [German]; Procarbazine Monohydrochloride; CB 400-497; Indicarb (TN); Matulane (TN); Natulan (TN); Procarbazina [INN-Spanish]; Procarbazine (INN); Procarbazine [INN:BAN]; Procarbazinum [INN-Latin];Ro 4-6467; SRI-10847; Ro 4-6467/1; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide; P-(2-Methylhydrazinomethyl)-N-isopropylbenzamide; N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide; P-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide; N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide; Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-(9CI); 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide
Drug Type
Small molecular drug
Indication Hodgkin's lymphoma [ICD10:C81] Approved [538480], [542298]
Therapeutic Class
Anticancer Agents
Company
Sigma-Tau Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C12H19N3O
InChI
InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
InChIKey
CPTBDICYNRMXFX-UHFFFAOYSA-N
CAS Number
CAS 671-16-9
PubChem Compound ID
4915
PubChem Substance ID
9606, 5227622, 7980389, 8153026, 10532324, 11112335, 11446055, 11451557, 11467140, 11468260, 11486848, 15195970, 29223993, 46507706, 47440427, 47736658, 47810931, 48259429, 48414372, 48416472, 49699412, 49857646, 50100422, 53790978, 57288818, 57322522, 60975981, 75023517, 92309185, 92720556, 93166341, 96025109, 103411217, 104224963, 104307787, 119525894, 125564988, 126619890, 126653077, 126667406, 127660052, 134338256, 134977726, 136342514, 137001449, 140349398, 144076104, 144212055, 152030630, 160655721
SuperDrug ATC ID
L01XB01
SuperDrug CAS ID
cas=000671169
Target and Pathway
Target(s) DNA Target Info [536874]
References
Ref 538480FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016785.
Ref 542298(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7278).
Ref 536874Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. DNA Repair (Amst). 2009 Jan 1;8(1):72-86. Epub 2008 Oct 21.

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