Drug Information

Drug General Information
Drug ID
D08HKT
Former ID
DIB008616
Drug Name
BEMORADAN
Synonyms
Orf-22867; RWJ-22867; Bemoradan < Rec INN >; Rac-7-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-2H-1,4-benzoxazin-3(4H)-one; Rac-5-Methyl-6-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-2,3,4,5-tetrahydropyridazin-3-one
Drug Type
Small molecular drug
Indication Heart failure [ICD9: 428; ICD10:I50] Phase 2 [526254]
Structure
Download
2D MOL

3D MOL
Formula
C13H13N3O3
Canonical SMILES
CC1CC(=O)NN=C1c2ccc3NC(=O)COc3c2
InChI
1S/C13H13N3O3/c1-7-4-11(17)15-16-13(7)8-2-3-9-10(5-8)19-6-12(18)14-9/h2-3,5,7H,4,6H2,1H3,(H,14,18)(H,15,17)
InChIKey
XZPGINPFWXLYNW-UHFFFAOYSA-N
CAS Number
CAS 112018-01-6
PubChem Compound ID
5362399
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [551871]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 526254Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs. Eur J Drug Metab Pharmacokinet. 2001 Oct-Dec;26(4):263-71.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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