Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08HVR
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| Former ID |
DIB006947
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| Drug Name |
Levodopa
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| Synonyms |
Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion
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| Drug Type |
Small molecular drug
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Approved | [1] | ||
| Company |
Orion Corp
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| Structure |
|
Download2D MOL |
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| Formula |
C9H11NO4
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| InChI |
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
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| InChIKey |
WTDRDQBEARUVNC-LURJTMIESA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3648, 222573, 555833, 3136680, 7847127, 7886892, 7979689, 8001566, 8143351, 8150164, 8153771, 10321285, 11111115, 11112155, 11335627, 11360866, 11363348, 11365910, 11368472, 11374316, 11376634, 11461838, 11466045, 11467165, 11484127, 11485710, 11488312, 11492354, 11494268, 11532916, 11537951, 15120911, 15219946, 17405017, 24277914, 24863554, 26613179, 26679497, 26719283, 26746620, 26753566, 29225059, 46508120, 47216726, 47291084, 47440197, 47440198, 47736420, 47810699, 47959681
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| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3639). | ||||
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